Assay Detail
Binding
CHEMBL862030
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Inhibition of [3H]NMS dissociation from muscarinic M2 receptor in hepes buffer
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
6H,13H-Pyrazino[1,2-a;4,5-a']diindole analogs: probing the pharmacophore for allosteric ligands of muscarinic M2 receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 5.12 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL206666 | — | — | 1 | 5.64 |
| CHEMBL382243 | — | — | 1 | 4.95 |
| CHEMBL203627 | — | — | 1 | 4.78 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL206666 | — | EC50 | = | 2290.87 | nM | 5.64 |
| CHEMBL382243 | — | EC50 | = | 11220.18 | nM | 4.95 |
| CHEMBL203627 | — | EC50 | = | 16595.87 | nM | 4.78 |