Assay Detail
Binding
CHEMBL862122
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Inhibition of human recombinant sPLA2 G1B
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
The first potent inhibitor of mammalian group X secreted phospholipase A2: elucidation of sites for enhanced binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.88 | 6.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148674 | VARESPLADIB | 2.0 | 1 | 6.12 |
| CHEMBL208315 | — | — | 1 | 6.10 |
| CHEMBL208429 | — | — | 1 | 5.70 |
| CHEMBL346196 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148674 | VARESPLADIB | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL208315 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL208429 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL346196 | — | IC50 | = | 2500.0 | nM | 5.60 |