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Assay Detail

CHEMBL862146

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Activity at human beta-2 adrenergic receptor expressed in CHO cells by stimulation of cAMP production
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Beta-2 adrenergic receptor (CHEMBL210)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonists.
Uehling DE, Shearer BG, Donaldson KH, Chao EY, Deaton DN, Adkison KK, Brown KK, Cariello NF, Faison WL, Lancaster ME, Lin J, Hart R, Milliken TO, Paulik MA, Sherman BW, Sugg EE, Cowan C.
J Med Chem (2006) 49 : 2758 -2771
PubMed 16640337 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 15 6.51 9.80

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL434 ISOPROTERENOL 4.0 1 9.80
CHEMBL205224 1 7.30
CHEMBL154419 1 7.30
CHEMBL152535 1 7.30
CHEMBL208352 1 6.30
CHEMBL204827 1 6.20
CHEMBL377028 1 6.00
CHEMBL208427 SOLABEGRON 2.0 1 5.90
CHEMBL383511 1 5.80
CHEMBL208328 1 5.80
CHEMBL205389 1 5.40
CHEMBL424866 1 5.00
CHEMBL206002 1 -
CHEMBL347582 1 -
CHEMBL207943 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL434 ISOPROTERENOL EC50 = 0.1585 nM 9.80
CHEMBL205224 EC50 = 50.12 nM 7.30
CHEMBL154419 EC50 = 50.12 nM 7.30
CHEMBL152535 EC50 = 50.12 nM 7.30
CHEMBL208352 EC50 = 501.19 nM 6.30
CHEMBL204827 EC50 = 630.96 nM 6.20
CHEMBL377028 EC50 = 1000.0 nM 6.00
CHEMBL208427 SOLABEGRON EC50 = 1258.93 nM 5.90
CHEMBL383511 EC50 = 1584.89 nM 5.80
CHEMBL208328 EC50 = 1584.89 nM 5.80
CHEMBL205389 EC50 = 3981.07 nM 5.40
CHEMBL424866 EC50 = 10000.0 nM 5.00
CHEMBL206002 EC50 < 10000.0 nM -
CHEMBL347582 EC50 < 1000.0 nM -
CHEMBL207943 EC50 < 10000.0 nM -