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Assay Detail

CHEMBL862176

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of JNK3
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Mitogen-activated protein kinase 10 (CHEMBL2637)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.
Swahn BM, Xue Y, Arzel E, Kallin E, Magnus A, Plobeck N, Viklund J.
Bioorg Med Chem Lett (2006) 16 : 1397 -1401
PubMed 16337120 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 7.49 8.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL203839 2 8.52
CHEMBL202639 1 8.30
CHEMBL205078 1 8.22
CHEMBL203535 1 8.15
CHEMBL203059 1 8.10
CHEMBL203225 1 8.05
CHEMBL202666 1 8.00
CHEMBL206466 1 7.82
CHEMBL202676 1 7.82
CHEMBL205672 1 7.77
CHEMBL380724 1 7.75
CHEMBL379254 1 7.70
CHEMBL203009 1 7.50
CHEMBL203289 1 7.50
CHEMBL205402 1 7.48
CHEMBL204757 1 7.36
CHEMBL203792 1 6.97
CHEMBL380625 1 6.76
CHEMBL383678 1 6.68
CHEMBL203631 1 6.63
CHEMBL437706 1 6.28
CHEMBL205561 1 6.19
CHEMBL202961 1 6.16
CHEMBL383770 1 -
CHEMBL378591 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL203839 IC50 = 3.0 nM 8.52
CHEMBL202639 IC50 = 5.0 nM 8.30
CHEMBL205078 IC50 = 6.0 nM 8.22
CHEMBL203535 IC50 = 7.0 nM 8.15
CHEMBL203059 IC50 = 8.0 nM 8.10
CHEMBL203839 IC50 = 9.0 nM 8.05
CHEMBL203225 IC50 = 9.0 nM 8.05
CHEMBL202666 IC50 = 10.0 nM 8.00
CHEMBL206466 IC50 = 15.0 nM 7.82
CHEMBL202676 IC50 = 15.0 nM 7.82
CHEMBL205672 IC50 = 17.0 nM 7.77
CHEMBL380724 IC50 = 18.0 nM 7.75
CHEMBL379254 IC50 = 20.0 nM 7.70
CHEMBL203009 IC50 = 32.0 nM 7.50
CHEMBL203289 IC50 = 32.0 nM 7.50
CHEMBL205402 IC50 = 33.0 nM 7.48
CHEMBL204757 IC50 = 44.0 nM 7.36
CHEMBL203792 IC50 = 108.0 nM 6.97
CHEMBL380625 IC50 = 175.0 nM 6.76
CHEMBL383678 IC50 = 207.0 nM 6.68
CHEMBL203631 IC50 = 235.0 nM 6.63
CHEMBL437706 IC50 = 528.0 nM 6.28
CHEMBL205561 IC50 = 652.0 nM 6.19
CHEMBL202961 IC50 = 693.0 nM 6.16
CHEMBL383770 IC50 > 10000.0 nM -
CHEMBL378591 IC50 > 10000.0 nM -