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Assay Detail

CHEMBL862178

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Binding
Inhibition of p38alpha
13
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Mitogen-activated protein kinase 14 (CHEMBL260)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Design and synthesis of 2'-anilino-4,4'-bipyridines as selective inhibitors of c-Jun N-terminal kinase-3.
Swahn BM, Xue Y, Arzel E, Kallin E, Magnus A, Plobeck N, Viklund J.
Bioorg Med Chem Lett (2006) 16 : 1397 -1401
PubMed 16337120 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 6.84 7.43

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL203225 1 7.43
CHEMBL202676 1 7.40
CHEMBL202639 1 7.30
CHEMBL202666 1 6.79
CHEMBL206466 1 6.77
CHEMBL203535 1 6.75
CHEMBL205078 1 6.70
CHEMBL203059 1 6.60
CHEMBL203839 2 6.38
CHEMBL383678 1 -
CHEMBL203631 1 -
CHEMBL204757 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL203225 IC50 = 37.0 nM 7.43
CHEMBL202676 IC50 = 40.0 nM 7.40
CHEMBL202639 IC50 = 50.0 nM 7.30
CHEMBL202666 IC50 = 162.0 nM 6.79
CHEMBL206466 IC50 = 171.0 nM 6.77
CHEMBL203535 IC50 = 180.0 nM 6.75
CHEMBL205078 IC50 = 199.0 nM 6.70
CHEMBL203059 IC50 = 251.0 nM 6.60
CHEMBL203839 IC50 = 421.0 nM 6.38
CHEMBL203839 IC50 = 581.0 nM 6.24
CHEMBL383678 IC50 - -
CHEMBL203631 IC50 - -
CHEMBL204757 IC50 - -