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Assay Detail

CHEMBL862191

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type kidney
Confidence 9 — Direct single protein target
Curated By Expert

Target

Vascular endothelial growth factor receptor 2 (CHEMBL279)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Hetaryl imidazoles: a novel dual inhibitors of VEGF receptors I and II.
Kiselyov AS, Semenova M, Semenov VV, Piatnitski E, Ouyang S.
Bioorg Med Chem Lett (2006) 16 : 1440 -1444
PubMed 16321531 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 31 6.66 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL101253 VATALANIB 3.0 1 7.68
CHEMBL202011 1 7.30
CHEMBL203796 1 7.19
CHEMBL383255 1 7.18
CHEMBL380131 1 7.09
CHEMBL153843 1 7.05
CHEMBL378592 1 7.03
CHEMBL205884 1 7.02
CHEMBL205127 1 7.00
CHEMBL206538 1 6.89
CHEMBL204874 1 6.58
CHEMBL202892 1 6.57
CHEMBL203056 1 6.24
CHEMBL379908 1 6.19
CHEMBL203731 1 5.98
CHEMBL203119 1 5.94
CHEMBL24828 VANDETANIB 4.0 1 5.78
CHEMBL203394 1 5.25
CHEMBL204312 1 -
CHEMBL383126 1 -
CHEMBL206267 1 -
CHEMBL205464 1 -
CHEMBL205463 1 -
CHEMBL379239 1 -
CHEMBL378165 1 -
CHEMBL203789 1 -
CHEMBL202904 1 -
CHEMBL382672 1 -
CHEMBL206118 1 -
CHEMBL206742 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL101253 VATALANIB IC50 = 21.0 nM 7.68
CHEMBL202011 IC50 = 50.0 nM 7.30
CHEMBL203796 IC50 = 64.0 nM 7.19
CHEMBL383255 IC50 = 66.0 nM 7.18
CHEMBL380131 IC50 = 82.0 nM 7.09
CHEMBL153843 IC50 = 90.0 nM 7.05
CHEMBL378592 IC50 = 93.0 nM 7.03
CHEMBL205884 IC50 = 96.0 nM 7.02
CHEMBL205127 IC50 = 100.0 nM 7.00
CHEMBL206538 IC50 = 130.0 nM 6.89
CHEMBL204874 IC50 = 260.0 nM 6.58
CHEMBL202892 IC50 = 270.0 nM 6.57
CHEMBL203056 IC50 = 570.0 nM 6.24
CHEMBL379908 IC50 = 640.0 nM 6.19
CHEMBL203731 IC50 = 1050.0 nM 5.98
CHEMBL203119 IC50 = 1150.0 nM 5.94
CHEMBL24828 VANDETANIB IC50 = 1660.0 nM 5.78
CHEMBL203394 IC50 = 5650.0 nM 5.25
CHEMBL204312 IC50 - -
CHEMBL383126 IC50 - -
CHEMBL206267 IC50 - -
CHEMBL205464 IC50 - -
CHEMBL205463 IC50 - -
CHEMBL379239 IC50 - -
CHEMBL378165 IC50 > 10000.0 nM -
CHEMBL203789 IC50 - -
CHEMBL202904 IC50 > 10000.0 nM -
CHEMBL382672 IC50 > 10000.0 nM -
CHEMBL206118 IC50 > 10000.0 nM -
CHEMBL206742 IC50 > 10000.0 nM -
CHEMBL204718 IC50 > 10000.0 nM -