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Assay Detail

CHEMBL862229

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against wild-type HIV1 in MT2 cells by MTT assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Intermediate

Target

Human immunodeficiency virus 1 (CHEMBL378)
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Computer-aided design of non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Jorgensen WL, Ruiz-Caro J, Tirado-Rives J, Basavapathruni A, Anderson KS, Hamilton AD.
Bioorg Med Chem Lett (2006) 16 : 663 -667
PubMed 16263277 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 24 6.25 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL54893 UC 781 1.0 1 8.70
CHEMBL372166 1 8.00
CHEMBL381722 1 7.75
CHEMBL201874 1 7.19
CHEMBL201357 1 7.12
CHEMBL57 NEVIRAPINE 4.0 1 6.92
CHEMBL202247 1 6.70
CHEMBL372355 1 6.68
CHEMBL202620 1 6.52
CHEMBL202269 1 5.55
CHEMBL201779 1 5.52
CHEMBL991 STAVUDINE 4.0 1 5.52
CHEMBL380575 1 5.50
CHEMBL372077 1 5.42
CHEMBL201778 1 5.30
CHEMBL369995 1 5.00
CHEMBL202174 1 4.64
CHEMBL202268 1 4.52
CHEMBL202186 1 -
CHEMBL201151 1 -
CHEMBL202178 1 -
CHEMBL202707 1 -
CHEMBL201689 1 -
CHEMBL308954 ETRAVIRINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL54893 UC 781 EC50 = 2.0 nM 8.70
CHEMBL372166 EC50 = 10.0 nM 8.00
CHEMBL381722 EC50 = 18.0 nM 7.75
CHEMBL201874 EC50 = 65.0 nM 7.19
CHEMBL201357 EC50 = 75.0 nM 7.12
CHEMBL57 NEVIRAPINE EC50 = 120.0 nM 6.92
CHEMBL202247 EC50 = 200.0 nM 6.70
CHEMBL372355 EC50 = 210.0 nM 6.68
CHEMBL202620 EC50 = 300.0 nM 6.52
CHEMBL202269 EC50 = 2800.0 nM 5.55
CHEMBL201779 EC50 = 3000.0 nM 5.52
CHEMBL991 STAVUDINE EC50 = 3000.0 nM 5.52
CHEMBL380575 EC50 = 3200.0 nM 5.50
CHEMBL372077 EC50 = 3800.0 nM 5.42
CHEMBL201778 EC50 = 5000.0 nM 5.30
CHEMBL369995 EC50 = 10000.0 nM 5.00
CHEMBL202174 EC50 = 23000.0 nM 4.64
CHEMBL202268 EC50 = 30000.0 nM 4.52
CHEMBL202186 EC50 - -
CHEMBL201151 EC50 - -
CHEMBL202178 EC50 - -
CHEMBL202707 EC50 - -
CHEMBL201689 EC50 - -
CHEMBL308954 ETRAVIRINE EC50 < 2.0 nM -