Assay Detail
Binding
CHEMBL862242
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Inhibitory activity against EGFR kinase
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.08 | 5.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200976 | — | — | 1 | 5.55 |
| CHEMBL78257 | TYRPHOSTIN 51 | — | 1 | 5.39 |
| CHEMBL202162 | — | — | 1 | 5.29 |
| CHEMBL202244 | — | — | 1 | 5.05 |
| CHEMBL201840 | — | — | 1 | 4.90 |
| CHEMBL383030 | — | — | 1 | 4.87 |
| CHEMBL201865 | — | — | 1 | 4.51 |
| CHEMBL202216 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200976 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL78257 | TYRPHOSTIN 51 | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL202162 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL202244 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL201840 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL383030 | — | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL201865 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL202216 | — | IC50 | > | 50000.0 | nM | - |