Assay Detail
Functional
CHEMBL862280
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Cytotoxicity against human promyelocytic leukemia HL60 cell line
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Miliusanes, a class of cytotoxic agents from Miliusa sinensis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.59 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440759 | — | — | 1 | 6.50 |
| CHEMBL381302 | — | — | 1 | 6.35 |
| CHEMBL381859 | — | — | 1 | 6.25 |
| CHEMBL2448545 | (+)-MILIUSANE XVIII | — | 1 | 6.20 |
| CHEMBL382849 | — | — | 1 | 6.18 |
| CHEMBL425038 | — | — | 1 | 5.76 |
| CHEMBL383534 | — | — | 1 | 5.48 |
| CHEMBL380413 | — | — | 1 | 5.48 |
| CHEMBL383650 | — | — | 1 | 4.73 |
| CHEMBL201503 | — | — | 1 | 4.28 |
| CHEMBL383494 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440759 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL381302 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL381859 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2448545 | (+)-MILIUSANE XVIII | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL382849 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL425038 | — | IC50 | = | 1730.0 | nM | 5.76 |
| CHEMBL383534 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL380413 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL383650 | — | IC50 | = | 18660.0 | nM | 4.73 |
| CHEMBL201503 | — | IC50 | = | 52290.0 | nM | 4.28 |
| CHEMBL383494 | — | IC50 | = | 57010.0 | nM | 4.24 |