Assay Detail
Binding
CHEMBL862409
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Inhibition of human AChE
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of huperzine A-tacrine hybrids as potent inhibitors of human cholinesterases targeting their midgorge recognition sites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 8.09 | 10.59 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208599 | HUPRINE X | — | 1 | 10.59 |
| CHEMBL210453 | — | — | 1 | 8.19 |
| CHEMBL382423 | — | — | 1 | 7.80 |
| CHEMBL208092 | — | — | 1 | 7.78 |
| CHEMBL395280 | HUPERZINE A | 2.0 | 1 | 7.33 |
| CHEMBL95 | TACRINE | 4.0 | 1 | 6.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208599 | HUPRINE X | Ki | = | 0.026 | nM | 10.59 |
| CHEMBL210453 | — | Ki | = | 6.4 | nM | 8.19 |
| CHEMBL382423 | — | Ki | = | 15.7 | nM | 7.80 |
| CHEMBL208092 | — | Ki | = | 16.5 | nM | 7.78 |
| CHEMBL395280 | HUPERZINE A | Ki | = | 47.0 | nM | 7.33 |
| CHEMBL95 | TACRINE | Ki | = | 137.0 | nM | 6.86 |