Assay Detail
Functional
CHEMBL862459
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Antiproliferative activity against human NCI-H460 cell line by MTT assay
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H460 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Activity of nitrogen-containing and non-nitrogen-containing bisphosphonates on tumor cell lines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 65 | 4.60 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL212835 | — | — | 1 | 6.21 |
| CHEMBL213206 | — | — | 1 | 5.79 |
| CHEMBL378256 | — | — | 1 | 5.57 |
| CHEMBL212842 | — | — | 1 | 5.31 |
| CHEMBL212662 | — | — | 1 | 5.25 |
| CHEMBL214851 | — | — | 1 | 5.24 |
| CHEMBL213327 | — | — | 1 | 5.22 |
| CHEMBL4303669 | ZOLEDRONIC ACID | 4.0 | 1 | 4.93 |
| CHEMBL294191 | — | — | 1 | 4.90 |
| CHEMBL373332 | — | — | 1 | 4.83 |
| CHEMBL363434 | — | — | 1 | 4.73 |
| CHEMBL212843 | — | — | 1 | 4.70 |
| CHEMBL386831 | — | — | 1 | 4.67 |
| CHEMBL212792 | — | — | 1 | 4.65 |
| CHEMBL56073 | — | — | 1 | 4.64 |
| CHEMBL383962 | — | — | 1 | 4.63 |
| CHEMBL383957 | — | — | 1 | 4.48 |
| CHEMBL441692 | — | — | 1 | 4.38 |
| CHEMBL923 | RISEDRONIC ACID | 4.0 | 1 | 4.36 |
| CHEMBL385291 | — | — | 1 | 4.33 |
| CHEMBL192342 | — | — | 1 | 4.28 |
| CHEMBL378940 | — | — | 1 | 4.27 |
| CHEMBL378354 | — | — | 1 | 4.26 |
| CHEMBL215119 | — | — | 1 | 4.24 |
| CHEMBL386386 | — | — | 1 | 4.23 |
| CHEMBL213343 | — | — | 1 | 4.21 |
| CHEMBL384601 | — | — | 1 | 4.21 |
| CHEMBL294192 | — | — | 1 | 4.20 |
| CHEMBL193722 | — | — | 1 | 4.18 |
| CHEMBL193356 | — | — | 1 | 4.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL212835 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL213206 | — | IC50 | = | 1640.0 | nM | 5.79 |
| CHEMBL378256 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL212842 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL212662 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL214851 | — | IC50 | = | 5730.0 | nM | 5.24 |
| CHEMBL213327 | — | IC50 | = | 5950.0 | nM | 5.22 |
| CHEMBL4303669 | ZOLEDRONIC ACID | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL294191 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL373332 | — | IC50 | = | 14800.0 | nM | 4.83 |
| CHEMBL363434 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL212843 | — | IC50 | = | 20100.0 | nM | 4.70 |
| CHEMBL386831 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL212792 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL56073 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL383962 | — | IC50 | = | 23200.0 | nM | 4.63 |
| CHEMBL383957 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL441692 | — | IC50 | = | 41300.0 | nM | 4.38 |
| CHEMBL923 | RISEDRONIC ACID | IC50 | = | 43700.0 | nM | 4.36 |
| CHEMBL385291 | — | IC50 | = | 46900.0 | nM | 4.33 |
| CHEMBL192342 | — | IC50 | = | 52200.0 | nM | 4.28 |
| CHEMBL378940 | — | IC50 | = | 53700.0 | nM | 4.27 |
| CHEMBL378354 | — | IC50 | = | 54500.0 | nM | 4.26 |
| CHEMBL215119 | — | IC50 | = | 58100.0 | nM | 4.24 |
| CHEMBL386386 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL213343 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL384601 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL294192 | — | IC50 | = | 63700.0 | nM | 4.20 |
| CHEMBL193722 | — | IC50 | = | 65800.0 | nM | 4.18 |
| CHEMBL193356 | — | IC50 | = | 66800.0 | nM | 4.17 |
| CHEMBL191634 | — | IC50 | = | 69900.0 | nM | 4.16 |
| CHEMBL834 | PAMIDRONIC ACID | IC50 | = | 71800.0 | nM | 4.14 |
| CHEMBL192043 | — | IC50 | = | 71700.0 | nM | 4.14 |
| CHEMBL193619 | — | IC50 | = | 74400.0 | nM | 4.13 |
| CHEMBL215608 | — | IC50 | = | 86100.0 | nM | 4.07 |
| CHEMBL213470 | — | IC50 | = | 92900.0 | nM | 4.03 |
| CHEMBL213490 | — | IC50 | = | 140000.0 | nM | - |
| CHEMBL213463 | — | IC50 | = | 133000.0 | nM | - |
| CHEMBL214544 | — | IC50 | = | 132000.0 | nM | - |
| CHEMBL213280 | — | IC50 | = | 284000.0 | nM | - |
| CHEMBL215413 | — | IC50 | = | 285000.0 | nM | - |
| CHEMBL377025 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL378858 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL213489 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL385542 | — | IC50 | = | 413000.0 | nM | - |
| CHEMBL216027 | — | IC50 | = | 329000.0 | nM | - |
| CHEMBL386646 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL215664 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL213289 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL213059 | — | IC50 | > | 10000000.0 | nM | - |