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Assay Detail

CHEMBL862460

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Functional
Antiproliferative activity against human SF-268 cell line by MTT assay
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type SF-268
Confidence 1 — Organism
Curated By Expert

Target

SF-268 (CHEMBL613977)
Type CELL-LINE
Organism Homo sapiens

Publication

Activity of nitrogen-containing and non-nitrogen-containing bisphosphonates on tumor cell lines.
Zhang Y, Leon A, Song Y, Studer D, Haase C, Koscielski LA, Oldfield E.
J Med Chem (2006) 49 : 5804 -5814
PubMed 16970405 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 65 4.67 6.19

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL212835 1 6.19
CHEMBL378256 1 5.84
CHEMBL213206 1 5.62
CHEMBL212842 1 5.32
CHEMBL214851 1 5.21
CHEMBL212662 1 5.19
CHEMBL212792 1 5.11
CHEMBL213327 1 5.10
CHEMBL383962 1 4.98
CHEMBL373332 1 4.88
CHEMBL4303669 ZOLEDRONIC ACID 4.0 1 4.84
CHEMBL294191 1 4.84
CHEMBL386831 1 4.63
CHEMBL923 RISEDRONIC ACID 4.0 1 4.63
CHEMBL383957 1 4.62
CHEMBL192342 1 4.57
CHEMBL212843 1 4.55
CHEMBL193619 1 4.51
CHEMBL441692 1 4.36
CHEMBL385291 1 4.35
CHEMBL213343 1 4.35
CHEMBL384601 1 4.35
CHEMBL192043 1 4.34
CHEMBL191634 1 4.33
CHEMBL56073 1 4.31
CHEMBL193722 1 4.31
CHEMBL193356 1 4.28
CHEMBL378354 1 4.25
CHEMBL215608 1 4.24
CHEMBL215119 1 4.23

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL212835 IC50 = 650.0 nM 6.19
CHEMBL378256 IC50 = 1430.0 nM 5.84
CHEMBL213206 IC50 = 2380.0 nM 5.62
CHEMBL212842 IC50 = 4780.0 nM 5.32
CHEMBL214851 IC50 = 6180.0 nM 5.21
CHEMBL212662 IC50 = 6500.0 nM 5.19
CHEMBL212792 IC50 = 7770.0 nM 5.11
CHEMBL213327 IC50 = 7890.0 nM 5.10
CHEMBL383962 IC50 = 10400.0 nM 4.98
CHEMBL373332 IC50 = 13100.0 nM 4.88
CHEMBL4303669 ZOLEDRONIC ACID IC50 = 14300.0 nM 4.84
CHEMBL294191 IC50 = 14400.0 nM 4.84
CHEMBL923 RISEDRONIC ACID IC50 = 23300.0 nM 4.63
CHEMBL386831 IC50 = 23200.0 nM 4.63
CHEMBL383957 IC50 = 24100.0 nM 4.62
CHEMBL192342 IC50 = 27200.0 nM 4.57
CHEMBL212843 IC50 = 28300.0 nM 4.55
CHEMBL193619 IC50 = 30700.0 nM 4.51
CHEMBL441692 IC50 = 43600.0 nM 4.36
CHEMBL385291 IC50 = 44700.0 nM 4.35
CHEMBL213343 IC50 = 44600.0 nM 4.35
CHEMBL384601 IC50 = 44800.0 nM 4.35
CHEMBL192043 IC50 = 45800.0 nM 4.34
CHEMBL191634 IC50 = 46800.0 nM 4.33
CHEMBL193722 IC50 = 49300.0 nM 4.31
CHEMBL56073 IC50 = 49200.0 nM 4.31
CHEMBL193356 IC50 = 52600.0 nM 4.28
CHEMBL378354 IC50 = 55700.0 nM 4.25
CHEMBL215608 IC50 = 58000.0 nM 4.24
CHEMBL215119 IC50 = 58300.0 nM 4.23
CHEMBL384308 IC50 = 65100.0 nM 4.19
CHEMBL363434 IC50 = 67000.0 nM 4.17
CHEMBL386386 IC50 = 72700.0 nM 4.14
CHEMBL378940 IC50 = 89300.0 nM 4.05
CHEMBL213490 IC50 = 130000.0 nM -
CHEMBL213463 IC50 = 143000.0 nM -
CHEMBL214544 IC50 = 175000.0 nM -
CHEMBL215413 IC50 = 303000.0 nM -
CHEMBL385542 IC50 = 620000.0 nM -
CHEMBL216027 IC50 = 475000.0 nM -
CHEMBL212182 IC50 = 349000.0 nM -
CHEMBL436939 IC50 = 290000.0 nM -
CHEMBL213470 IC50 = 109000.0 nM -
CHEMBL214519 IC50 > 10000000.0 nM -
CHEMBL377025 IC50 > 10000000.0 nM -
CHEMBL378858 IC50 > 10000000.0 nM -
CHEMBL213489 IC50 > 10000000.0 nM -
CHEMBL386646 IC50 > 10000000.0 nM -
CHEMBL215664 IC50 > 10000000.0 nM -
CHEMBL213059 IC50 > 10000000.0 nM -