Assay Detail
Binding
CHEMBL862463
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Inhibition of tubulin polymerization in porcine brain
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Tubulin polymerization inhibitors with a fluorinated phthalimide skeleton derived from thalidomide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.96 | 5.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313952 | — | — | 1 | 5.16 |
| CHEMBL377049 | — | — | 1 | 5.11 |
| CHEMBL330174 | — | — | 1 | 4.80 |
| CHEMBL213924 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313952 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL377049 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL330174 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL213924 | — | IC50 | = | 17000.0 | nM | 4.77 |