Assay Detail
Binding
CHEMBL862512
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Inhibition of erbB1 fusion protein expressed in baculovirus by ELISA
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB family of tyrosine kinase receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 8.57 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91867 | — | — | 1 | 9.70 |
| CHEMBL203644 | — | — | 1 | 9.52 |
| CHEMBL203599 | — | — | 1 | 9.30 |
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 9.22 |
| CHEMBL378144 | — | — | 1 | 9.22 |
| CHEMBL205059 | — | — | 1 | 9.05 |
| CHEMBL437890 | — | — | 1 | 8.96 |
| CHEMBL203661 | — | — | 1 | 8.89 |
| CHEMBL202411 | — | — | 1 | 8.85 |
| CHEMBL204638 | — | — | 1 | 8.82 |
| CHEMBL202360 | — | — | 1 | 8.80 |
| CHEMBL204085 | — | — | 1 | 8.77 |
| CHEMBL203645 | — | — | 1 | 8.77 |
| CHEMBL382073 | — | — | 1 | 8.74 |
| CHEMBL545315 | CANERTINIB DIHYDROCHLORIDE | 3.0 | 1 | 8.52 |
| CHEMBL202556 | — | — | 1 | 8.51 |
| CHEMBL939 | GEFITINIB | 4.0 | 1 | 8.51 |
| CHEMBL373207 | — | — | 1 | 8.51 |
| CHEMBL380669 | — | — | 1 | 8.38 |
| CHEMBL202424 | — | — | 1 | 7.82 |
| CHEMBL202425 | — | — | 1 | 7.82 |
| CHEMBL202421 | — | — | 1 | 7.77 |
| CHEMBL202398 | — | — | 1 | 7.40 |
| CHEMBL383499 | — | — | 1 | 7.36 |
| CHEMBL202621 | — | — | 1 | 7.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91867 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL203644 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL203599 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL553 | ERLOTINIB | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL378144 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL205059 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL437890 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL203661 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL202411 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL204638 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL202360 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL204085 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL203645 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL382073 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL545315 | CANERTINIB DIHYDROCHLORIDE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL202556 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL939 | GEFITINIB | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL373207 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL380669 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL202424 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL202425 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL202421 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL202398 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL383499 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL202621 | — | IC50 | = | 86.0 | nM | 7.07 |