Assay Detail
Binding
CHEMBL862664
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Inhibition of Helicobacter pylori recombinant CA
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Helicobacter pylori |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Carbonic anhydrase (CHEMBL4211) ↗| Type | SINGLE PROTEIN |
| Organism | Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacterpylori) |
Publication
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 35 | 6.50 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 7.70 |
| CHEMBL266240 | — | — | 1 | 7.39 |
| CHEMBL6633 | — | — | 1 | 7.14 |
| CHEMBL360356 | — | — | 1 | 7.08 |
| CHEMBL7146 | — | — | 1 | 7.02 |
| CHEMBL266026 | — | — | 1 | 6.91 |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | 6.81 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | 6.77 |
| CHEMBL6685 | — | — | 1 | 6.76 |
| CHEMBL26 | SULPIRIDE | 3.0 | 1 | 6.75 |
| CHEMBL220492 | TOPIRAMATE | 4.0 | 1 | 6.69 |
| CHEMBL268439 | — | — | 1 | 6.67 |
| CHEMBL750 | ZONISAMIDE | 4.0 | 1 | 6.66 |
| CHEMBL220491 | BRINZOLAMIDE | 4.0 | 1 | 6.61 |
| CHEMBL73962 | BENZOLAMIDE | — | 1 | 6.54 |
| CHEMBL265674 | — | — | 1 | 6.51 |
| CHEMBL7204 | — | — | 1 | 6.48 |
| CHEMBL17 | DICHLORPHENAMIDE | 4.0 | 1 | 6.44 |
| CHEMBL7092 | — | — | 1 | 6.40 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | — | 1 | 6.40 |
| CHEMBL21 | SULFANILAMIDE | 4.0 | 1 | 6.37 |
| CHEMBL77517 | INDISULAM | 2.0 | 1 | 6.36 |
| CHEMBL6724 | — | — | 1 | 6.33 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | 3.0 | 1 | 6.33 |
| CHEMBL6705 | — | — | 1 | 6.33 |
| CHEMBL6753 | — | — | 1 | 6.31 |
| CHEMBL268177 | — | — | 1 | 6.30 |
| CHEMBL176495 | — | — | 1 | 6.25 |
| CHEMBL419 | MAFENIDE | 4.0 | 1 | 6.08 |
| CHEMBL6919 | — | — | 1 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL266240 | — | Ki | = | 41.0 | nM | 7.39 |
| CHEMBL6633 | — | Ki | = | 72.0 | nM | 7.14 |
| CHEMBL360356 | — | Ki | = | 84.0 | nM | 7.08 |
| CHEMBL7146 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL266026 | — | Ki | = | 124.0 | nM | 6.91 |
| CHEMBL18 | ETHOXZOLAMIDE | Ki | = | 155.0 | nM | 6.81 |
| CHEMBL19 | METHAZOLAMIDE | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL6685 | — | Ki | = | 174.0 | nM | 6.76 |
| CHEMBL26 | SULPIRIDE | Ki | = | 179.0 | nM | 6.75 |
| CHEMBL220492 | TOPIRAMATE | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL268439 | — | Ki | = | 213.0 | nM | 6.67 |
| CHEMBL750 | ZONISAMIDE | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL220491 | BRINZOLAMIDE | Ki | = | 246.0 | nM | 6.61 |
| CHEMBL73962 | BENZOLAMIDE | Ki | = | 287.0 | nM | 6.54 |
| CHEMBL265674 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL7204 | — | Ki | = | 334.0 | nM | 6.48 |
| CHEMBL17 | DICHLORPHENAMIDE | Ki | = | 363.0 | nM | 6.44 |
| CHEMBL418 | 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE | Ki | = | 402.0 | nM | 6.40 |
| CHEMBL7092 | — | Ki | = | 395.0 | nM | 6.40 |
| CHEMBL21 | SULFANILAMIDE | Ki | = | 431.0 | nM | 6.37 |
| CHEMBL77517 | INDISULAM | Ki | = | 434.0 | nM | 6.36 |
| CHEMBL6724 | — | Ki | = | 463.0 | nM | 6.33 |
| CHEMBL574 | P-TOLUENESULFONAMIDE | Ki | = | 473.0 | nM | 6.33 |
| CHEMBL6705 | — | Ki | = | 465.0 | nM | 6.33 |
| CHEMBL6753 | — | Ki | = | 494.0 | nM | 6.31 |
| CHEMBL268177 | — | Ki | = | 504.0 | nM | 6.30 |
| CHEMBL176495 | — | Ki | = | 562.0 | nM | 6.25 |
| CHEMBL419 | MAFENIDE | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL6919 | — | Ki | = | 870.0 | nM | 6.06 |
| CHEMBL7087 | — | Ki | = | 1035.0 | nM | 5.99 |
| CHEMBL414 | CARZENIDE | Ki | = | 1083.0 | nM | 5.96 |
| CHEMBL6784 | — | Ki | = | 1157.0 | nM | 5.94 |
| CHEMBL6853 | — | Ki | = | 1310.0 | nM | 5.88 |
| CHEMBL218490 | DORZOLAMIDE | Ki | = | 4310.0 | nM | 5.37 |