Assay Detail
Functional
CHEMBL862702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro bone resorption in isolated rabbit osteoclasts
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Cell Type | Osteoclast |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.64 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL200708 | — | — | 1 | 9.00 |
| CHEMBL200494 | — | — | 1 | 8.52 |
| CHEMBL198798 | — | — | 1 | 8.52 |
| CHEMBL200602 | — | — | 1 | 8.40 |
| CHEMBL426819 | — | — | 1 | 8.30 |
| CHEMBL200543 | — | — | 1 | 8.10 |
| CHEMBL435913 | — | — | 1 | 8.00 |
| CHEMBL200596 | — | — | 1 | 7.96 |
| CHEMBL414669 | — | — | 1 | 7.96 |
| CHEMBL200672 | — | — | 1 | 7.89 |
| CHEMBL200287 | — | — | 1 | 7.72 |
| CHEMBL370165 | — | — | 1 | 7.70 |
| CHEMBL200426 | — | — | 1 | 7.70 |
| CHEMBL199214 | — | — | 1 | 7.68 |
| CHEMBL198802 | — | — | 1 | 7.62 |
| CHEMBL381190 | — | — | 1 | 7.48 |
| CHEMBL200788 | — | — | 1 | 7.46 |
| CHEMBL199358 | — | — | 1 | 7.46 |
| CHEMBL199014 | — | — | 1 | 7.43 |
| CHEMBL199163 | — | — | 1 | 7.40 |
| CHEMBL200744 | — | — | 1 | 7.37 |
| CHEMBL200166 | — | — | 1 | 7.34 |
| CHEMBL200507 | — | — | 1 | 7.28 |
| CHEMBL372410 | — | — | 1 | 7.23 |
| CHEMBL200506 | — | — | 1 | 7.22 |
| CHEMBL200455 | — | — | 1 | 7.21 |
| CHEMBL371133 | — | — | 1 | 7.11 |
| CHEMBL199470 | — | — | 1 | 6.96 |
| CHEMBL381026 | — | — | 1 | 6.68 |
| CHEMBL197440 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL200708 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL200494 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL198798 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL200602 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL426819 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL200543 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL435913 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL200596 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL414669 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL200672 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL200287 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL370165 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL200426 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL199214 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL198802 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL381190 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL200788 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL199358 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL199014 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL199163 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL200744 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL200166 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL200507 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL372410 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL200506 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL200455 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL371133 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL199470 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL381026 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL197440 | — | IC50 | = | 320.0 | nM | 6.50 |