Compound Detail
CHEMBL198798
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N#CCNC(=O)C1(NC(=O)c2ccc(-c3csc(N4CCC(N5CCCCC5)CC4)n3)cc2)CCCCC1
Basic Information
| ChEMBL ID | CHEMBL198798 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FSOSJHXWNDUEFL-UHFFFAOYSA-N |
5
Targets
5
Activities
2
Assay Types
3
PK Parameters
6
Publications
0
Known Names
Molecular Properties
534.7
MW (Da)
4.34
ALogP
7
HBA
2
HBD
101.4
PSA (Ų)
0.51
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 9.35
IC50 1 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cathepsin K CHEMBL3349 | Ki | 9.35 | 9.35 | 0.5 | 1 |
| Osteoclast CHEMBL612548 | IC50 | 8.52 | 8.52 | 3.0 | 1 |
| Cathepsin B CHEMBL4072 | Ki | 6.16 | 6.16 | 690.0 | 1 |
| Procathepsin L CHEMBL3837 | Ki | 5.06 | 5.06 | 8800.0 | 1 |
| Cathepsin S CHEMBL2954 | Ki | 4.38 | 4.38 | 42000.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 360.0 | nM | Rattus norvegicus |
| F | 35.0 | % | Rattus norvegicus |
| T1/2 | 3.35 | hr | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cathepsin K | Ki | = | 0.45 | nM | 9.35 | Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrate | 16302794 |
| Osteoclast | IC50 | = | 3.0 | nM | 8.52 | In vitro bone resorption in isolated rabbit osteoclasts | 16302794 |
| Cathepsin B | Ki | = | 690.0 | nM | 6.16 | Inhibitory constant against human cathepsin B using Boc-Leu-Lys-Arg-AMC substrat... | 16302794 |
| Procathepsin L | Ki | = | 8800.0 | nM | 5.06 | Inhibitory constant against human cathepsin L using Z-Phe-Arg-AMC substrate | 16302794 |
| Cathepsin S | Ki | = | 42000.0 | nM | 4.38 | Inhibitory constant against human cathepsin S using Z-Val-Val-Arg-AMC substrate | 16302794 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16302794 | 10.1021/jm058198r | Rattus norvegicus | 3 |
| 16302794 | 10.1021/jm058198r | Cathepsin K | 1 |
| 16302794 | 10.1021/jm058198r | Cathepsin B | 1 |
| 16302794 | 10.1021/jm058198r | Procathepsin L | 1 |
| 16302794 | 10.1021/jm058198r | Cathepsin S | 1 |
| 16302794 | 10.1021/jm058198r | Osteoclast | 1 |
Data from ChEMBL 36 via Core Engine