Assay Detail
Functional
CHEMBL862781
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Effect on [35S]GTP-gamma-S binding to human CB2 receptor
18
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.75 | 8.68 |
| Emax | 9 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL381689 | SR-144528 | — | 2 | 8.68 |
| CHEMBL307696 | — | — | 2 | 8.39 |
| CHEMBL559612 | CP-55940 | — | 2 | 8.21 |
| CHEMBL372544 | — | — | 2 | 7.85 |
| CHEMBL200143 | — | — | 2 | 7.78 |
| CHEMBL264521 | — | — | 2 | 7.61 |
| CHEMBL188 | WIN-552122 | — | 2 | 7.61 |
| CHEMBL371214 | — | — | 2 | 6.84 |
| CHEMBL380610 | — | — | 2 | 6.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL381689 | SR-144528 | EC50 | = | 2.1 | nM | 8.68 |
| CHEMBL307696 | — | EC50 | = | 4.1 | nM | 8.39 |
| CHEMBL559612 | CP-55940 | EC50 | = | 6.1 | nM | 8.21 |
| CHEMBL372544 | — | EC50 | = | 14.1 | nM | 7.85 |
| CHEMBL200143 | — | EC50 | = | 16.8 | nM | 7.78 |
| CHEMBL188 | WIN-552122 | EC50 | = | 24.6 | nM | 7.61 |
| CHEMBL264521 | — | EC50 | = | 24.8 | nM | 7.61 |
| CHEMBL371214 | — | EC50 | = | 145.6 | nM | 6.84 |
| CHEMBL380610 | — | EC50 | = | 157.4 | nM | 6.80 |
| CHEMBL264521 | — | Emax | = | 126.0 | % | - |
| CHEMBL307696 | — | Emax | = | 135.1 | % | - |
| CHEMBL371214 | — | Emax | = | 149.0 | % | - |
| CHEMBL559612 | CP-55940 | Emax | = | 145.6 | % | - |
| CHEMBL381689 | SR-144528 | Emax | = | 21.6 | % | - |
| CHEMBL380610 | — | Emax | = | 123.5 | % | - |
| CHEMBL200143 | — | Emax | = | 128.7 | % | - |
| CHEMBL372544 | — | Emax | = | 124.1 | % | - |
| CHEMBL188 | WIN-552122 | Emax | = | 126.2 | % | - |