Assay Detail
Functional
CHEMBL862847
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Inhibition of C5a-mediated PKB/Akt phosphorylation in mouse Raw264 macrophage
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Furan-2-ylmethylene thiazolidinediones as novel, potent, and selective inhibitors of phosphoinositide 3-kinase gamma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.14 | 9.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL208652 | — | — | 1 | 9.09 |
| CHEMBL379156 | — | — | 1 | 6.64 |
| CHEMBL377152 | — | — | 1 | 6.14 |
| CHEMBL211768 | — | — | 1 | 6.06 |
| CHEMBL377104 | — | — | 1 | 5.97 |
| CHEMBL209159 | — | — | 1 | 5.86 |
| CHEMBL377175 | — | — | 1 | 5.77 |
| CHEMBL211173 | — | — | 1 | 5.46 |
| CHEMBL378528 | — | — | 1 | 5.44 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL208652 | — | IC50 | = | 0.81 | nM | 9.09 |
| CHEMBL379156 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL377152 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL211768 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL377104 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL209159 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL377175 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL211173 | — | IC50 | = | 3490.0 | nM | 5.46 |
| CHEMBL378528 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL98350 | LY-294002 | IC50 | = | 10000.0 | nM | 5.00 |