Assay Detail
Functional
CHEMBL862855
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Inhibition of VEGF-mediated proliferation of HMVEC
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HMEC |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 6.62 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL377230 | — | — | 1 | 8.40 |
| CHEMBL212054 | — | — | 1 | 7.48 |
| CHEMBL383417 | — | — | 1 | 7.11 |
| CHEMBL211662 | — | — | 1 | 7.10 |
| CHEMBL208600 | — | — | 1 | 7.01 |
| CHEMBL378299 | — | — | 1 | 7.01 |
| CHEMBL380372 | — | — | 1 | 6.89 |
| CHEMBL209783 | — | — | 1 | 6.80 |
| CHEMBL377346 | — | — | 1 | 6.72 |
| CHEMBL212429 | — | — | 1 | 6.66 |
| CHEMBL379108 | — | — | 1 | 6.66 |
| CHEMBL209704 | — | — | 1 | 6.66 |
| CHEMBL379740 | — | — | 1 | 6.62 |
| CHEMBL208775 | — | — | 1 | 6.57 |
| CHEMBL209265 | — | — | 1 | 6.52 |
| CHEMBL378024 | — | — | 1 | 6.46 |
| CHEMBL425247 | — | — | 1 | 6.34 |
| CHEMBL211940 | — | — | 1 | 5.85 |
| CHEMBL379995 | — | — | 1 | 5.75 |
| CHEMBL383990 | — | — | 1 | 5.23 |
| CHEMBL378003 | — | — | 1 | 5.16 |
| CHEMBL211708 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL377230 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL212054 | — | EC50 | = | 33.0 | nM | 7.48 |
| CHEMBL383417 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL211662 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL208600 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL378299 | — | EC50 | = | 97.0 | nM | 7.01 |
| CHEMBL380372 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL209783 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL377346 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL212429 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL379108 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL209704 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL379740 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL208775 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL209265 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL378024 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL425247 | — | EC50 | = | 460.0 | nM | 6.34 |
| CHEMBL211940 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL379995 | — | EC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL383990 | — | EC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL378003 | — | EC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL211708 | — | EC50 | > | 10000.0 | nM | - |