Compound Detail
CHEMBL425247
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c1ccc(COc2cccc3[nH]nc(-c4nc5cc(N6CCC(N7CCCCC7)CC6)ccc5[nH]4)c23)cc1
Basic Information
| ChEMBL ID | CHEMBL425247 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WDNZQFHFETZMGC-UHFFFAOYSA-N |
5
Targets
5
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
506.6
MW (Da)
6.14
ALogP
5
HBA
2
HBD
73.1
PSA (Ų)
0.29
QED
2
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.2
EC50 1 meas. best 6.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 1 CHEMBL1868 | IC50 | 7.2 | 7.2 | 63.0 | 1 |
| Fibroblast growth factor receptor 1 CHEMBL3650 | IC50 | 7.03 | 7.03 | 94.0 | 1 |
| HMEC CHEMBL614734 | EC50 | 6.34 | 6.34 | 460.0 | 1 |
| Vascular endothelial growth factor receptor 2 CHEMBL3337 | IC50 | 6.18 | 6.18 | 660.0 | 1 |
| Platelet-derived growth factor receptor beta CHEMBL2749 | IC50 | 5.75 | 5.75 | 1800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Vascular endothelial growth factor receptor 1 | IC50 | = | 63.0 | nM | 7.2 | Inhibition of VEGFR1 | 16603352 |
| Fibroblast growth factor receptor 1 | IC50 | = | 94.0 | nM | 7.03 | Inhibition of FGFR1 | 16603352 |
| HMEC | EC50 | = | 460.0 | nM | 6.34 | Inhibition of VEGF-mediated proliferation of HMVEC | 16603352 |
| Vascular endothelial growth factor receptor 2 | IC50 | = | 660.0 | nM | 6.18 | Inhibition of VEGFR2 | 16603352 |
| Platelet-derived growth factor receptor beta | IC50 | = | 1800.0 | nM | 5.75 | Inhibition of PDGFRbeta | 16603352 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16603352 | 10.1016/j.bmcl.2006.03.069 | HMEC | 1 |
| 16603352 | 10.1016/j.bmcl.2006.03.069 | Fibroblast growth factor receptor 1 | 1 |
| 16603352 | 10.1016/j.bmcl.2006.03.069 | Platelet-derived growth factor receptor beta | 1 |
| 16603352 | 10.1016/j.bmcl.2006.03.069 | Vascular endothelial growth factor receptor 1 | 1 |
| 16603352 | 10.1016/j.bmcl.2006.03.069 | Vascular endothelial growth factor receptor 2 | 1 |
Data from ChEMBL 36 via Core Engine