Assay Detail
Binding
CHEMBL862851
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of FGFR1
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and structure-activity relationship of 3-benzimidazol-2-yl-1H-indazoles as inhibitors of receptor tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 7.37 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL378024 | — | — | 1 | 9.00 |
| CHEMBL377230 | — | — | 1 | 8.70 |
| CHEMBL379740 | — | — | 1 | 8.52 |
| CHEMBL377346 | — | — | 1 | 8.10 |
| CHEMBL211662 | — | — | 1 | 7.82 |
| CHEMBL379108 | — | — | 1 | 7.80 |
| CHEMBL212429 | — | — | 1 | 7.75 |
| CHEMBL209704 | — | — | 1 | 7.64 |
| CHEMBL212054 | — | — | 1 | 7.55 |
| CHEMBL378299 | — | — | 1 | 7.32 |
| CHEMBL380372 | — | — | 1 | 7.14 |
| CHEMBL208600 | — | — | 1 | 7.09 |
| CHEMBL425247 | — | — | 1 | 7.03 |
| CHEMBL208775 | — | — | 1 | 7.01 |
| CHEMBL209783 | — | — | 1 | 7.00 |
| CHEMBL211940 | — | — | 1 | 6.70 |
| CHEMBL378003 | — | — | 1 | 6.68 |
| CHEMBL209265 | — | — | 1 | 6.57 |
| CHEMBL211708 | — | — | 1 | 6.08 |
| CHEMBL383990 | — | — | 1 | 5.85 |
| CHEMBL379995 | — | — | 1 | - |
| CHEMBL212262 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL378024 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL377230 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL379740 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL377346 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL211662 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL379108 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL212429 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL209704 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL212054 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL378299 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL380372 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL208600 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL425247 | — | IC50 | = | 94.0 | nM | 7.03 |
| CHEMBL208775 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL209783 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL211940 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL378003 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL209265 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL211708 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL383990 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL379995 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL212262 | — | IC50 | > | 3000.0 | nM | - |