Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL863014

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against HIV1
ChEMBL ↗
100
Total Activities
100
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Human immunodeficiency virus 1
Confidence 1 — Organism
Curated By Expert

Target

Human immunodeficiency virus 1 (CHEMBL378) ↗
Type ORGANISM
Organism Human immunodeficiency virus 1

Publication

Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide.
Ragno R, Coluccia A, La Regina G, De Martino G, Piscitelli F, Lavecchia A, Novellino E, Bergamini A, Ciaprini C, Sinistro A, Maga G, Crespan E, Artico M, Silvestri R.
J Med Chem (2006) 49 : 3172 -3184
PubMed 16722636 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 100 6.76 9.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL366702 — — 1 9.10
CHEMBL176239 — — 1 9.00
CHEMBL82106 — — 1 9.00
CHEMBL83800 — — 1 9.00
CHEMBL283950 L-737126 — 1 9.00
CHEMBL210282 — — 1 9.00
CHEMBL82533 — — 1 8.70
CHEMBL84217 — — 1 8.52
CHEMBL379904 — — 1 8.52
CHEMBL85059 — — 1 8.40
CHEMBL315349 — — 1 8.40
CHEMBL312702 — — 1 8.22
CHEMBL180522 — — 1 8.15
CHEMBL366914 — — 1 8.10
CHEMBL81097 — — 1 8.00
CHEMBL378773 — — 1 8.00
CHEMBL263503 — — 1 7.96
CHEMBL210493 — — 1 7.92
CHEMBL80045 — — 1 7.85
CHEMBL84002 — — 1 7.82
CHEMBL286759 — — 1 7.70
CHEMBL310319 — — 1 7.60
CHEMBL209348 — — 1 7.52
CHEMBL207134 — — 1 7.51
CHEMBL209671 — — 1 7.40
CHEMBL180330 — — 1 7.40
CHEMBL312251 — — 1 7.40
CHEMBL377202 — — 1 7.37
CHEMBL419108 — — 1 7.30
CHEMBL207385 — — 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL366702 — EC50 = 0.8 nM 9.10
CHEMBL176239 — EC50 = 1.0 nM 9.00
CHEMBL210282 — EC50 = 1.0 nM 9.00
CHEMBL283950 L-737126 EC50 = 1.0 nM 9.00
CHEMBL82106 — EC50 = 1.0 nM 9.00
CHEMBL83800 — EC50 = 1.0 nM 9.00
CHEMBL82533 — EC50 = 2.0 nM 8.70
CHEMBL84217 — EC50 = 3.0 nM 8.52
CHEMBL379904 — EC50 = 3.0 nM 8.52
CHEMBL85059 — EC50 = 4.0 nM 8.40
CHEMBL315349 — EC50 = 4.0 nM 8.40
CHEMBL312702 — EC50 = 6.0 nM 8.22
CHEMBL180522 — EC50 = 7.0 nM 8.15
CHEMBL366914 — EC50 = 8.0 nM 8.10
CHEMBL81097 — EC50 = 10.0 nM 8.00
CHEMBL378773 — EC50 = 10.0 nM 8.00
CHEMBL263503 — EC50 = 11.0 nM 7.96
CHEMBL210493 — EC50 = 12.0 nM 7.92
CHEMBL80045 — EC50 = 14.0 nM 7.85
CHEMBL84002 — EC50 = 15.0 nM 7.82
CHEMBL286759 — EC50 = 20.0 nM 7.70
CHEMBL310319 — EC50 = 25.0 nM 7.60
CHEMBL209348 — EC50 = 30.0 nM 7.52
CHEMBL207134 — EC50 = 31.0 nM 7.51
CHEMBL312251 — EC50 = 40.0 nM 7.40
CHEMBL180330 — EC50 = 40.0 nM 7.40
CHEMBL209671 — EC50 = 40.0 nM 7.40
CHEMBL377202 — EC50 = 43.0 nM 7.37
CHEMBL419108 — EC50 = 50.0 nM 7.30
CHEMBL207385 — EC50 = 50.0 nM 7.30
CHEMBL208799 — EC50 = 50.0 nM 7.30
CHEMBL381183 — EC50 = 80.0 nM 7.10
CHEMBL425244 — EC50 = 80.0 nM 7.10
CHEMBL314697 — EC50 = 80.0 nM 7.10
CHEMBL79797 — EC50 = 100.0 nM 7.00
CHEMBL207156 — EC50 = 100.0 nM 7.00
CHEMBL209246 — EC50 = 100.0 nM 7.00
CHEMBL382002 — EC50 = 120.0 nM 6.92
CHEMBL84522 — EC50 = 130.0 nM 6.89
CHEMBL80022 — EC50 = 130.0 nM 6.89
CHEMBL431798 — EC50 = 180.0 nM 6.75
CHEMBL79337 — EC50 = 190.0 nM 6.72
CHEMBL210810 — EC50 = 200.0 nM 6.70
CHEMBL310464 — EC50 = 300.0 nM 6.52
CHEMBL83495 — EC50 = 300.0 nM 6.52
CHEMBL311605 — EC50 = 300.0 nM 6.52
CHEMBL84101 — EC50 = 320.0 nM 6.50
CHEMBL79398 — EC50 = 530.0 nM 6.28
CHEMBL82471 — EC50 = 550.0 nM 6.26
CHEMBL378109 — EC50 = 600.0 nM 6.22