Assay Detail
Functional
CHEMBL863021
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 3B in MT4 cell line
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 7.85 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL383700 | — | — | 1 | 9.15 |
| CHEMBL207361 | — | — | 1 | 9.00 |
| CHEMBL223228 | EFAVIRENZ | 4.0 | 1 | 8.40 |
| CHEMBL382230 | — | — | 1 | 8.30 |
| CHEMBL126603 | — | — | 1 | 8.00 |
| CHEMBL383724 | — | — | 1 | 7.82 |
| CHEMBL127048 | — | — | 1 | 7.70 |
| CHEMBL206990 | — | — | 1 | 7.70 |
| CHEMBL378236 | — | — | 1 | 7.40 |
| CHEMBL209228 | — | — | 1 | 7.30 |
| CHEMBL210336 | — | — | 1 | 7.00 |
| CHEMBL57 | NEVIRAPINE | 4.0 | 1 | 6.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL383700 | — | EC50 | = | 0.7 | nM | 9.15 |
| CHEMBL207361 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL223228 | EFAVIRENZ | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL382230 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL126603 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL383724 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL127048 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL206990 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL378236 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL209228 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL210336 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL57 | NEVIRAPINE | EC50 | = | 370.0 | nM | 6.43 |