Assay Detail
Functional
CHEMBL863023
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 K103N-Y181C mutant in MT4 cell line
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Design, molecular modeling, synthesis, and anti-HIV-1 activity of new indolyl aryl sulfones. Novel derivatives of the indole-2-carboxamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.48 | 6.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL207361 | — | — | 1 | 6.05 |
| CHEMBL126603 | — | — | 1 | 5.92 |
| CHEMBL127048 | — | — | 1 | 5.58 |
| CHEMBL378236 | — | — | 1 | 5.24 |
| CHEMBL383700 | — | — | 1 | 5.07 |
| CHEMBL206990 | — | — | 1 | 5.04 |
| CHEMBL383724 | — | — | 1 | - |
| CHEMBL382230 | — | — | 1 | - |
| CHEMBL210336 | — | — | 1 | - |
| CHEMBL209228 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL207361 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL126603 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL127048 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL378236 | — | EC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL383700 | — | EC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL206990 | — | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL383724 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL382230 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL210336 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL209228 | — | EC50 | > | 20000.0 | nM | - |