Assay Detail
Binding
CHEMBL863115
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]beta-CIT from DAT in rat caudate homogenate
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL338) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and monoamine transporter affinity of 2beta-carbomethoxy-3beta-(4'-p-substituted phenyl)-piperidine analogs of cocaine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.11 | 9.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL215376 | — | — | 1 | 9.02 |
| CHEMBL213921 | — | — | 1 | 6.91 |
| CHEMBL215988 | — | — | 1 | 6.71 |
| CHEMBL214567 | — | — | 1 | 6.69 |
| CHEMBL213823 | — | — | 1 | 6.22 |
| CHEMBL386244 | — | — | 1 | - |
| CHEMBL385645 | — | — | 1 | - |
| CHEMBL214618 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL215376 | — | Ki | = | 0.96 | nM | 9.02 |
| CHEMBL213921 | — | Ki | = | 123.0 | nM | 6.91 |
| CHEMBL215988 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL214567 | — | Ki | = | 205.0 | nM | 6.69 |
| CHEMBL213823 | — | Ki | = | 598.0 | nM | 6.22 |
| CHEMBL386244 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL385645 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL214618 | — | Ki | >= | 5000.0 | nM | - |