Assay Detail
Binding
CHEMBL863122
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Inhibition of human recombinant 11-beta-HSD2 expressed in HEK293 cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
11-beta-hydroxysteroid dehydrogenase type 2 (CHEMBL3746) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of new 11beta-hydroxysteroid dehydrogenase type 1 inhibitors by common feature pharmacophore modeling and virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.30 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL425772 | — | — | 1 | 7.22 |
| CHEMBL207413 | ACETOXOLONE | -1.0 | 1 | 6.70 |
| CHEMBL382614 | — | — | 1 | 6.55 |
| CHEMBL380677 | — | — | 1 | 5.63 |
| CHEMBL211039 | — | — | 1 | 5.40 |
| CHEMBL206908 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL425772 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL207413 | ACETOXOLONE | IC50 | = | 201.0 | nM | 6.70 |
| CHEMBL382614 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL380677 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL211039 | — | IC50 | = | 3950.0 | nM | 5.40 |
| CHEMBL206908 | — | IC50 | > | 30000.0 | nM | - |