Assay Detail
Binding
CHEMBL863149
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Inhibition of CDK2/cyclin A
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin A (CHEMBL2094128) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
A practical synthesis of the major 3-hydroxy-2-pyrrolidinone metabolite of a potent CDK2/cyclin A inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.52 | 7.57 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL380280 | — | — | 1 | 7.57 |
| CHEMBL381986 | — | — | 1 | 7.57 |
| CHEMBL191144 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL380280 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL381986 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL191144 | — | IC50 | = | 37.0 | nM | 7.43 |