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Assay Detail

CHEMBL863191

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against soybean 15LOX
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Glycine max
Confidence 9 — Direct single protein target
Curated By Expert

Target

Seed linoleate 13S-lipoxygenase-1 (CHEMBL4586)
Type SINGLE PROTEIN
Organism Glycine max

Publication

Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
Rao PN, Chen QH, Knaus EE.
J Med Chem (2006) 49 : 1668 -1683
PubMed 16509583 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 5.96 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL372548 1 7.00
CHEMBL196084 1 6.52
CHEMBL205080 1 6.52
CHEMBL194297 1 6.50
CHEMBL205120 1 6.44
CHEMBL204769 1 6.44
CHEMBL364739 1 6.30
CHEMBL427356 1 6.00
CHEMBL151 LUTEOLIN 2.0 1 5.50
CHEMBL197573 1 5.50
CHEMBL205131 1 5.50
CHEMBL362923 1 5.50
CHEMBL52 NORDIHYDROGUAIARETIC ACID 1 5.46
CHEMBL426488 1 5.46
CHEMBL371191 1 5.46
CHEMBL204795 1 5.30
CHEMBL194273 1 -
CHEMBL204130 1 -
CHEMBL193856 1 -
CHEMBL194897 1 -
CHEMBL194298 1 -
CHEMBL203459 1 -
CHEMBL194891 1 -
CHEMBL204796 1 -
CHEMBL204203 1 -
CHEMBL204293 1 -
CHEMBL203489 1 -
CHEMBL204865 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL372548 IC50 = 100.0 nM 7.00
CHEMBL196084 IC50 = 300.0 nM 6.52
CHEMBL205080 IC50 = 300.0 nM 6.52
CHEMBL194297 IC50 = 320.0 nM 6.50
CHEMBL205120 IC50 = 360.0 nM 6.44
CHEMBL204769 IC50 = 360.0 nM 6.44
CHEMBL364739 IC50 = 500.0 nM 6.30
CHEMBL427356 IC50 = 1000.0 nM 6.00
CHEMBL151 LUTEOLIN IC50 = 3200.0 nM 5.50
CHEMBL197573 IC50 = 3200.0 nM 5.50
CHEMBL205131 IC50 = 3200.0 nM 5.50
CHEMBL362923 IC50 = 3200.0 nM 5.50
CHEMBL52 NORDIHYDROGUAIARETIC ACID IC50 = 3500.0 nM 5.46
CHEMBL426488 IC50 = 3500.0 nM 5.46
CHEMBL371191 IC50 = 3500.0 nM 5.46
CHEMBL204795 IC50 = 5000.0 nM 5.30
CHEMBL194273 IC50 > 10000.0 nM -
CHEMBL204130 IC50 > 10000.0 nM -
CHEMBL193856 IC50 > 10000.0 nM -
CHEMBL194897 IC50 > 10000.0 nM -
CHEMBL194298 IC50 > 10000.0 nM -
CHEMBL203459 IC50 > 10000.0 nM -
CHEMBL194891 IC50 > 10000.0 nM -
CHEMBL204796 IC50 > 10000.0 nM -
CHEMBL204203 IC50 > 10000.0 nM -
CHEMBL204293 IC50 > 10000.0 nM -
CHEMBL203489 IC50 > 10000.0 nM -
CHEMBL204865 IC50 > 10000.0 nM -