Assay Detail
Functional
CHEMBL863302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Activity at rat mGluR6 by measuring cAMP formation in CHO cells
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Metabotropic glutamate receptor 6 (CHEMBL3842) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.21 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33567 | — | — | 1 | 6.47 |
| CHEMBL575060 | GLUTAMIC ACID | 3.0 | 1 | 5.12 |
| CHEMBL197976 | — | — | 1 | 4.89 |
| CHEMBL199626 | — | — | 1 | 4.34 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33567 | — | EC50 | = | 340.0 | nM | 6.47 |
| CHEMBL575060 | GLUTAMIC ACID | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL197976 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL199626 | — | EC50 | = | 46000.0 | nM | 4.34 |