Assay Detail
Functional
CHEMBL863344
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Inhibition of NMDA-evoked intracellular calcium increase in rat cortical cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Glutamate NMDA receptor (CHEMBL1907608) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Rattus norvegicus |
Publication
Indole-2-carboxamidines as novel NR2B selective NMDA receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 7.30 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL534486 | — | — | 1 | 8.27 |
| CHEMBL158737 | — | — | 1 | 8.18 |
| CHEMBL538825 | — | — | 1 | 7.77 |
| CHEMBL333936 | — | — | 1 | 7.75 |
| CHEMBL538081 | — | — | 1 | 7.72 |
| CHEMBL558984 | — | — | 1 | 7.58 |
| CHEMBL537860 | — | — | 1 | 7.48 |
| CHEMBL557803 | — | — | 1 | 7.46 |
| CHEMBL534485 | — | — | 1 | 7.19 |
| CHEMBL537192 | — | — | 1 | 7.16 |
| CHEMBL113919 | — | — | 1 | 6.88 |
| CHEMBL535826 | — | — | 1 | 6.84 |
| CHEMBL535828 | — | — | 1 | 6.80 |
| CHEMBL537418 | — | — | 1 | 6.77 |
| CHEMBL537417 | — | — | 1 | 6.63 |
| CHEMBL113830 | (S,R)-IFENPRODIL | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL534486 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL158737 | — | IC50 | = | 6.6 | nM | 8.18 |
| CHEMBL538825 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL333936 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL538081 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL558984 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL537860 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL557803 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL534485 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL537192 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL113919 | — | IC50 | = | 131.0 | nM | 6.88 |
| CHEMBL535826 | — | IC50 | = | 143.0 | nM | 6.84 |
| CHEMBL535828 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL537418 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL537417 | — | IC50 | = | 232.0 | nM | 6.63 |
| CHEMBL113830 | (S,R)-IFENPRODIL | IC50 | = | 470.0 | nM | 6.33 |