Assay Detail
Binding
CHEMBL863361
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Displacement of [125I]OVTA antagonist from rat oxytocin receptor expressed in HEK293-EBNA cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293-EBNA |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery and development of a new class of potent, selective, orally active oxytocin receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.87 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL445816 | — | — | 1 | 9.17 |
| CHEMBL2113189 | — | — | 1 | 8.57 |
| CHEMBL2113201 | — | — | 1 | 8.34 |
| CHEMBL2113185 | — | — | 1 | 8.10 |
| CHEMBL2113208 | — | — | 1 | 7.92 |
| CHEMBL2113203 | — | — | 1 | 7.82 |
| CHEMBL1254117 | — | — | 1 | 7.60 |
| CHEMBL2113177 | — | — | 1 | 7.60 |
| CHEMBL2113211 | — | — | 1 | 7.48 |
| CHEMBL382301 | ATOSIBAN | 4.0 | 1 | 7.12 |
| CHEMBL2113200 | — | — | 1 | 6.85 |
| CHEMBL2113181 | — | — | 1 | - |
| CHEMBL2113179 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL445816 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL2113189 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL2113201 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL2113185 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL2113208 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL2113203 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL1254117 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2113177 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2113211 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL382301 | ATOSIBAN | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL2113200 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL2113181 | — | Ki | - | — | - | |
| CHEMBL2113179 | — | Ki | - | — | - |