Assay Detail
Functional
CHEMBL863376
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 in the absence of human serum
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 34 | 7.59 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372805 | — | — | 1 | 8.52 |
| CHEMBL382521 | — | — | 1 | 8.52 |
| CHEMBL370440 | — | — | 1 | 8.40 |
| CHEMBL198998 | — | — | 1 | 8.40 |
| CHEMBL371319 | — | — | 1 | 8.40 |
| CHEMBL198713 | — | — | 1 | 8.40 |
| CHEMBL372632 | — | — | 1 | 8.40 |
| CHEMBL443030 | — | — | 1 | 8.40 |
| CHEMBL381875 | — | — | 1 | 8.30 |
| CHEMBL369925 | — | — | 1 | 8.22 |
| CHEMBL198952 | — | — | 1 | 8.05 |
| CHEMBL434185 | — | — | 1 | 8.05 |
| CHEMBL274258 | — | — | 1 | 8.05 |
| CHEMBL370397 | — | — | 1 | 7.89 |
| CHEMBL371092 | — | — | 1 | 7.82 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 7.80 |
| CHEMBL370795 | — | — | 1 | 7.77 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 7.66 |
| CHEMBL198478 | — | — | 1 | 7.52 |
| CHEMBL381629 | — | — | 1 | 7.43 |
| CHEMBL197434 | — | — | 1 | 7.35 |
| CHEMBL197318 | — | — | 1 | 7.35 |
| CHEMBL372625 | — | — | 1 | 7.30 |
| CHEMBL369926 | — | — | 1 | 7.28 |
| CHEMBL371090 | — | — | 1 | 7.27 |
| CHEMBL444621 | — | — | 1 | 7.21 |
| CHEMBL196772 | — | — | 1 | 7.13 |
| CHEMBL200296 | — | — | 1 | 7.07 |
| CHEMBL372131 | — | — | 1 | 6.82 |
| CHEMBL371085 | — | — | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372805 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL382521 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL370440 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL198998 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL371319 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL198713 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL372632 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL443030 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL381875 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL369925 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL198952 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL434185 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL274258 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL370397 | — | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL371092 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL370795 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL163 | RITONAVIR | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL198478 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL381629 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL197434 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL197318 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL372625 | — | EC50 | = | 50.0 | nM | 7.30 |
| CHEMBL369926 | — | EC50 | = | 53.0 | nM | 7.28 |
| CHEMBL371090 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL444621 | — | EC50 | = | 61.0 | nM | 7.21 |
| CHEMBL196772 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL200296 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL372131 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL371085 | — | EC50 | = | 212.0 | nM | 6.67 |
| CHEMBL198734 | — | EC50 | = | 308.0 | nM | 6.51 |
| CHEMBL370853 | — | EC50 | = | 572.0 | nM | 6.24 |
| CHEMBL372300 | — | EC50 | = | 929.0 | nM | 6.03 |
| CHEMBL434190 | — | EC50 | = | 1490.0 | nM | 5.83 |