Assay Detail
Functional
CHEMBL863378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 in the presence of 50% human serum
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 24 | 6.94 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL372805 | — | — | 1 | 7.80 |
| CHEMBL434185 | — | — | 1 | 7.75 |
| CHEMBL381875 | — | — | 1 | 7.57 |
| CHEMBL274258 | — | — | 1 | 7.57 |
| CHEMBL198713 | — | — | 1 | 7.55 |
| CHEMBL371319 | — | — | 1 | 7.55 |
| CHEMBL443030 | — | — | 1 | 7.54 |
| CHEMBL371092 | — | — | 1 | 7.33 |
| CHEMBL369925 | — | — | 1 | 7.32 |
| CHEMBL372632 | — | — | 1 | 7.25 |
| CHEMBL198998 | — | — | 1 | 7.25 |
| CHEMBL382521 | — | — | 1 | 7.22 |
| CHEMBL370440 | — | — | 1 | 7.21 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 7.17 |
| CHEMBL198952 | — | — | 1 | 7.11 |
| CHEMBL444621 | — | — | 1 | 6.78 |
| CHEMBL371090 | — | — | 1 | 6.45 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 6.32 |
| CHEMBL200296 | — | — | 1 | 6.32 |
| CHEMBL370853 | — | — | 1 | 6.31 |
| CHEMBL371085 | — | — | 1 | 6.26 |
| CHEMBL198734 | — | — | 1 | 6.24 |
| CHEMBL434190 | — | — | 1 | 5.49 |
| CHEMBL372300 | — | — | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL372805 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL434185 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL381875 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL274258 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL198713 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL371319 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL443030 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL371092 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL369925 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL372632 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL198998 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL382521 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL370440 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL198952 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL444621 | — | EC50 | = | 165.0 | nM | 6.78 |
| CHEMBL371090 | — | EC50 | = | 353.0 | nM | 6.45 |
| CHEMBL163 | RITONAVIR | EC50 | = | 483.0 | nM | 6.32 |
| CHEMBL200296 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL370853 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL371085 | — | EC50 | = | 546.0 | nM | 6.26 |
| CHEMBL198734 | — | EC50 | = | 576.0 | nM | 6.24 |
| CHEMBL434190 | — | EC50 | = | 3220.0 | nM | 5.49 |
| CHEMBL372300 | — | EC50 | = | 5150.0 | nM | 5.29 |