Assay Detail
Functional
CHEMBL863379
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against indinavir resistant HIV IND-R mutant strain
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.90 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370795 | — | — | 1 | 7.85 |
| CHEMBL370397 | — | — | 1 | 7.64 |
| CHEMBL198713 | — | — | 1 | 7.31 |
| CHEMBL198998 | — | — | 1 | 7.27 |
| CHEMBL196772 | — | — | 1 | 7.24 |
| CHEMBL372805 | — | — | 1 | 7.09 |
| CHEMBL369925 | — | — | 1 | 7.06 |
| CHEMBL274258 | — | — | 1 | 7.03 |
| CHEMBL372625 | — | — | 1 | 6.99 |
| CHEMBL382521 | — | — | 1 | 6.88 |
| CHEMBL371319 | — | — | 1 | 6.79 |
| CHEMBL198478 | — | — | 1 | 6.77 |
| CHEMBL434185 | — | — | 1 | 6.64 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 6.42 |
| CHEMBL369926 | — | — | 1 | 6.30 |
| CHEMBL197318 | — | — | 1 | 6.09 |
| CHEMBL200296 | — | — | 1 | 5.98 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370795 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL370397 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL198713 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL198998 | — | EC50 | = | 54.0 | nM | 7.27 |
| CHEMBL196772 | — | EC50 | = | 58.0 | nM | 7.24 |
| CHEMBL372805 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL369925 | — | EC50 | = | 88.0 | nM | 7.06 |
| CHEMBL274258 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL372625 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL382521 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL371319 | — | EC50 | = | 164.0 | nM | 6.79 |
| CHEMBL198478 | — | EC50 | = | 171.0 | nM | 6.77 |
| CHEMBL434185 | — | EC50 | = | 227.0 | nM | 6.64 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 385.0 | nM | 6.42 |
| CHEMBL369926 | — | EC50 | = | 504.0 | nM | 6.30 |
| CHEMBL197318 | — | EC50 | = | 821.0 | nM | 6.09 |
| CHEMBL200296 | — | EC50 | = | 1040.0 | nM | 5.98 |