Assay Detail
Functional
CHEMBL863382
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Lopinavir resistant HIV A17 mutant strain
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 20 | 6.42 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198998 | — | — | 1 | 7.19 |
| CHEMBL196772 | — | — | 1 | 7.08 |
| CHEMBL370397 | — | — | 1 | 7.01 |
| CHEMBL198713 | — | — | 1 | 6.99 |
| CHEMBL369925 | — | — | 1 | 6.88 |
| CHEMBL370795 | — | — | 1 | 6.72 |
| CHEMBL371319 | — | — | 1 | 6.72 |
| CHEMBL198478 | — | — | 1 | 6.51 |
| CHEMBL382521 | — | — | 1 | 6.43 |
| CHEMBL372805 | — | — | 1 | 6.34 |
| CHEMBL369926 | — | — | 1 | 6.33 |
| CHEMBL434185 | — | — | 1 | 6.25 |
| CHEMBL274258 | — | — | 1 | 6.23 |
| CHEMBL372625 | — | — | 1 | 6.05 |
| CHEMBL729 | LOPINAVIR | 4.0 | 1 | 5.97 |
| CHEMBL197318 | — | — | 1 | 5.97 |
| CHEMBL163 | RITONAVIR | 4.0 | 1 | 5.91 |
| CHEMBL197434 | — | — | 1 | 5.70 |
| CHEMBL381629 | — | — | 1 | 5.68 |
| CHEMBL200296 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198998 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL196772 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL370397 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL198713 | — | EC50 | = | 102.0 | nM | 6.99 |
| CHEMBL369925 | — | EC50 | = | 133.0 | nM | 6.88 |
| CHEMBL370795 | — | EC50 | = | 192.0 | nM | 6.72 |
| CHEMBL371319 | — | EC50 | = | 189.0 | nM | 6.72 |
| CHEMBL198478 | — | EC50 | = | 312.0 | nM | 6.51 |
| CHEMBL382521 | — | EC50 | = | 367.0 | nM | 6.43 |
| CHEMBL372805 | — | EC50 | = | 455.0 | nM | 6.34 |
| CHEMBL369926 | — | EC50 | = | 464.0 | nM | 6.33 |
| CHEMBL434185 | — | EC50 | = | 562.0 | nM | 6.25 |
| CHEMBL274258 | — | EC50 | = | 586.0 | nM | 6.23 |
| CHEMBL372625 | — | EC50 | = | 897.0 | nM | 6.05 |
| CHEMBL729 | LOPINAVIR | EC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL197318 | — | EC50 | = | 1070.0 | nM | 5.97 |
| CHEMBL163 | RITONAVIR | EC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL197434 | — | EC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL381629 | — | EC50 | = | 2070.0 | nM | 5.68 |
| CHEMBL200296 | — | EC50 | > | 10000.0 | nM | - |