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Assay Detail

CHEMBL863394

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]R-PIA from human adenosine A1 receptor transfected in CHO cells
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine receptor A1 (CHEMBL226)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationships of 2-chloro-N6-substituted-4'-thioadenosine-5'-uronamides as highly potent and selective agonists at the human A3 adenosine receptor.
Jeong LS, Lee HW, Jacobson KA, Kim HO, Shin DH, Lee JA, Gao ZG, Lu C, Duong HT, Gunaga P, Lee SK, Jin DZ, Chun MW, Moon HR.
J Med Chem (2006) 49 : 273 -281
PubMed 16392812 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 6.90 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL202189 1 8.70
CHEMBL200705 1 8.49
CHEMBL381868 1 8.34
CHEMBL381408 1 7.86
CHEMBL200184 1 7.43
CHEMBL199877 1 7.32
CHEMBL200072 1 7.12
CHEMBL200099 1 7.12
CHEMBL203357 1 7.05
CHEMBL370446 1 7.04
CHEMBL200407 1 6.90
CHEMBL200854 1 6.84
CHEMBL200732 1 6.71
CHEMBL370187 1 6.29
CHEMBL201427 1 6.20
CHEMBL201706 1 5.88
CHEMBL199414 1 5.77
CHEMBL200279 1 5.76
CHEMBL199541 1 5.70
CHEMBL201324 1 5.39

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL202189 Ki = 2.0 nM 8.70
CHEMBL200705 Ki = 3.2 nM 8.49
CHEMBL381868 Ki = 4.6 nM 8.34
CHEMBL381408 Ki = 13.9 nM 7.86
CHEMBL200184 Ki = 37.3 nM 7.43
CHEMBL199877 Ki = 47.8 nM 7.32
CHEMBL200072 Ki = 76.7 nM 7.12
CHEMBL200099 Ki = 75.8 nM 7.12
CHEMBL203357 Ki = 89.2 nM 7.05
CHEMBL370446 Ki = 92.0 nM 7.04
CHEMBL200407 Ki = 126.0 nM 6.90
CHEMBL200854 Ki = 144.0 nM 6.84
CHEMBL200732 Ki = 193.0 nM 6.71
CHEMBL370187 Ki = 507.0 nM 6.29
CHEMBL201427 Ki = 638.0 nM 6.20
CHEMBL201706 Ki = 1330.0 nM 5.88
CHEMBL199414 Ki = 1710.0 nM 5.77
CHEMBL200279 Ki = 1720.0 nM 5.76
CHEMBL199541 Ki = 1980.0 nM 5.70
CHEMBL201324 Ki = 4070.0 nM 5.39