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Assay Detail

CHEMBL863430

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of chemotaxis of murine CCR4 transfected L1.2 cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mus musculus
Cell Type L1.2
Confidence 8 — Homologous single protein target
Curated By Expert

Target

C-C chemokine receptor type 4 (CHEMBL2414)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Optimization of CCR4 antagonists: side-chain exploration.
Purandare AV, Wan H, Gao A, Somerville J, Burke C, Vaccaro W, Yang X, McIntyre KW, Poss MA.
Bioorg Med Chem Lett (2006) 16 : 204 -207
PubMed 16236499 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 6.42 6.42

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL372399 1 6.42

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL372399 IC50 = 380.0 nM 6.42