Assay Detail
Binding
CHEMBL863477
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Inhibitory activity against COX2 in canine whole blood
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canis lupus familiaris |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
5-heteroatom substituted pyrazoles as canine COX-2 inhibitors. Part 1: Structure-activity relationship studies of 5-alkylamino pyrazoles and discovery of a potent, selective, and orally active analog.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.62 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370579 | — | — | 1 | 7.52 |
| CHEMBL201696 | — | — | 1 | 7.20 |
| CHEMBL199344 | — | — | 1 | 7.02 |
| CHEMBL199992 | — | — | 1 | 6.96 |
| CHEMBL380595 | — | — | 1 | 6.94 |
| CHEMBL199991 | — | — | 1 | 6.90 |
| CHEMBL199337 | — | — | 1 | 6.90 |
| CHEMBL199346 | — | — | 1 | 6.89 |
| CHEMBL197705 | — | — | 1 | 6.89 |
| CHEMBL199431 | — | — | 1 | 6.88 |
| CHEMBL200518 | — | — | 1 | 6.85 |
| CHEMBL201179 | — | — | 1 | 6.85 |
| CHEMBL198024 | — | — | 1 | 6.84 |
| CHEMBL198189 | — | — | 1 | 6.82 |
| CHEMBL199901 | — | — | 1 | 6.72 |
| CHEMBL381251 | — | — | 1 | 6.72 |
| CHEMBL382095 | — | — | 1 | 6.71 |
| CHEMBL200152 | — | — | 1 | 6.70 |
| CHEMBL197869 | — | — | 1 | 6.70 |
| CHEMBL199682 | — | — | 1 | 6.68 |
| CHEMBL381879 | — | — | 1 | 6.64 |
| CHEMBL200812 | — | — | 1 | 6.62 |
| CHEMBL382524 | — | — | 1 | 6.53 |
| CHEMBL174219 | — | — | 1 | 6.51 |
| CHEMBL372393 | — | — | 1 | 6.44 |
| CHEMBL200406 | — | — | 1 | 6.44 |
| CHEMBL199681 | — | — | 1 | 6.38 |
| CHEMBL426475 | — | — | 1 | 5.90 |
| CHEMBL200559 | — | — | 1 | 5.73 |
| CHEMBL200909 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370579 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL201696 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL199344 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL199992 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL380595 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL199991 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL199337 | — | IC50 | = | 125.0 | nM | 6.90 |
| CHEMBL199346 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL197705 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL199431 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL200518 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL201179 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL198024 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL198189 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL199901 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL381251 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL382095 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL200152 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL197869 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL199682 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL381879 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL200812 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL382524 | — | IC50 | = | 297.0 | nM | 6.53 |
| CHEMBL174219 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL372393 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL200406 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL199681 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL426475 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL200559 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL200909 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL383151 | — | IC50 | = | 7900.0 | nM | 5.10 |