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Assay Detail

CHEMBL863514

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibitory activity against CDK1/Cyclin B from starfish oocytes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Marthasterias glacialis
Cell Type Oocyte
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Synthesis and biological evaluation of novel phenylcarbazoles as potential anticancer agents.
Routier S, Mérour JY, Dias N, Lansiaux A, Bailly C, Lozach O, Meijer L.
J Med Chem (2006) 49 : 789 -799
PubMed 16420063 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.17 6.24

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL202935 1 6.24
CHEMBL421087 1 4.10
CHEMBL378359 1 -
CHEMBL383097 1 -
CHEMBL201382 1 -
CHEMBL201418 1 -
CHEMBL201114 1 -
CHEMBL202979 1 -
CHEMBL382056 1 -
CHEMBL197700 1 -
CHEMBL382906 1 -
CHEMBL380656 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL202935 IC50 = 580.0 nM 6.24
CHEMBL421087 IC50 = 80000.0 nM 4.10
CHEMBL378359 IC50 > 10000.0 nM -
CHEMBL383097 IC50 > 10000.0 nM -
CHEMBL201382 IC50 > 10000.0 nM -
CHEMBL201418 IC50 > 10000.0 nM -
CHEMBL201114 IC50 > 10000.0 nM -
CHEMBL202979 IC50 > 10000.0 nM -
CHEMBL382056 IC50 > 10000.0 nM -
CHEMBL197700 IC50 > 10000.0 nM -
CHEMBL382906 IC50 > 10000.0 nM -
CHEMBL380656 IC50 > 10000.0 nM -