Assay Detail
Functional
CHEMBL863515
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Antiviral activity against HIV1 3B in MT4 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT4 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.01 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275658 | — | — | 1 | 9.00 |
| CHEMBL201526 | — | — | 1 | 8.30 |
| CHEMBL370201 | — | — | 1 | 8.22 |
| CHEMBL202929 | — | — | 1 | 8.22 |
| CHEMBL202663 | — | — | 1 | 8.15 |
| CHEMBL199539 | — | — | 1 | 8.10 |
| CHEMBL199506 | — | — | 1 | 8.00 |
| CHEMBL200988 | — | — | 1 | 7.75 |
| CHEMBL201084 | — | — | 1 | 7.60 |
| CHEMBL203425 | — | — | 1 | 7.43 |
| CHEMBL201352 | — | — | 1 | 7.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275658 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL201526 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL370201 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL202929 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL202663 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL199539 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL199506 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL200988 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL201084 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL203425 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL201352 | — | IC50 | = | 41.0 | nM | 7.39 |