Assay Detail
Functional
CHEMBL863516
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against HIV1 HxB2 using HeLa MAGI assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Structure-activity relationship studies of novel benzophenones leading to the discovery of a potent, next generation HIV nonnucleoside reverse transcriptase inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 8.37 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275658 | — | — | 1 | 8.70 |
| CHEMBL199539 | — | — | 1 | 8.52 |
| CHEMBL202663 | — | — | 1 | 8.52 |
| CHEMBL202929 | — | — | 1 | 8.40 |
| CHEMBL370201 | — | — | 1 | 8.22 |
| CHEMBL201084 | — | — | 1 | 8.10 |
| CHEMBL199506 | — | — | 1 | 8.10 |
| CHEMBL201526 | — | — | 1 | - |
| CHEMBL201352 | — | — | 1 | - |
| CHEMBL200988 | — | — | 1 | - |
| CHEMBL203425 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275658 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL199539 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL202663 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL202929 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL370201 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL201084 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL199506 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL201526 | — | IC50 | - | — | - | |
| CHEMBL201352 | — | IC50 | - | — | - | |
| CHEMBL200988 | — | IC50 | - | — | - | |
| CHEMBL203425 | — | IC50 | - | — | - |