Assay Detail
Functional
CHEMBL863540
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Activity against 5HT2B receptor in longitudinal stomach fundus strips in wistar rats
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Stomach |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.06 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL371300 | — | — | 1 | 8.70 |
| CHEMBL31115 | — | — | 1 | 8.57 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 8.46 |
| CHEMBL275854 | — | — | 1 | 8.38 |
| CHEMBL199775 | — | — | 1 | 8.38 |
| CHEMBL373245 | — | — | 1 | 8.23 |
| CHEMBL197653 | — | — | 1 | 8.21 |
| CHEMBL199385 | — | — | 1 | 8.07 |
| CHEMBL200104 | — | — | 1 | 8.05 |
| CHEMBL134519 | — | — | 1 | 7.92 |
| CHEMBL437314 | — | — | 1 | 7.07 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 6.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL371300 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL31115 | — | EC50 | = | 2.7 | nM | 8.57 |
| CHEMBL39 | SEROTONIN | EC50 | = | 3.5 | nM | 8.46 |
| CHEMBL275854 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL199775 | — | EC50 | = | 4.2 | nM | 8.38 |
| CHEMBL373245 | — | EC50 | = | 5.9 | nM | 8.23 |
| CHEMBL197653 | — | EC50 | = | 6.1 | nM | 8.21 |
| CHEMBL199385 | — | EC50 | = | 8.6 | nM | 8.07 |
| CHEMBL200104 | — | EC50 | = | 8.9 | nM | 8.05 |
| CHEMBL134519 | — | EC50 | = | 11.9 | nM | 7.92 |
| CHEMBL437314 | — | EC50 | = | 85.0 | nM | 7.07 |
| CHEMBL7257 | MEBUFOTENIN | EC50 | = | 240.0 | nM | 6.62 |