Assay Detail
Functional
CHEMBL863541
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Activity against recombinant rat 5HT2C mediated intracellular calcium mobilization by FLIPR in SR3T3 cells
24
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | SR3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 12 | 8.10 | 8.74 |
| Emax | 12 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275854 | — | — | 2 | 8.74 |
| CHEMBL39 | SEROTONIN | 3.0 | 2 | 8.55 |
| CHEMBL31115 | — | — | 2 | 8.51 |
| CHEMBL371300 | — | — | 2 | 8.43 |
| CHEMBL199385 | — | — | 2 | 8.35 |
| CHEMBL373245 | — | — | 2 | 8.31 |
| CHEMBL197653 | — | — | 2 | 8.26 |
| CHEMBL199775 | — | — | 2 | 8.17 |
| CHEMBL200104 | — | — | 2 | 8.14 |
| CHEMBL134519 | — | — | 2 | 7.52 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 2 | 7.11 |
| CHEMBL437314 | — | — | 2 | 7.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275854 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL39 | SEROTONIN | EC50 | = | 2.8 | nM | 8.55 |
| CHEMBL31115 | — | EC50 | = | 3.1 | nM | 8.51 |
| CHEMBL371300 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL199385 | — | EC50 | = | 4.5 | nM | 8.35 |
| CHEMBL373245 | — | EC50 | = | 4.9 | nM | 8.31 |
| CHEMBL197653 | — | EC50 | = | 5.5 | nM | 8.26 |
| CHEMBL199775 | — | EC50 | = | 6.7 | nM | 8.17 |
| CHEMBL200104 | — | EC50 | = | 7.3 | nM | 8.14 |
| CHEMBL134519 | — | EC50 | = | 30.2 | nM | 7.52 |
| CHEMBL7257 | MEBUFOTENIN | EC50 | = | 77.8 | nM | 7.11 |
| CHEMBL437314 | — | EC50 | = | 87.3 | nM | 7.06 |
| CHEMBL371300 | — | Emax | = | 89.0 | % | - |
| CHEMBL134519 | — | Emax | = | 84.0 | % | - |
| CHEMBL199385 | — | Emax | = | 104.0 | % | - |
| CHEMBL275854 | — | Emax | = | 100.0 | % | - |
| CHEMBL39 | SEROTONIN | Emax | = | 94.0 | % | - |
| CHEMBL437314 | — | Emax | = | 97.0 | % | - |
| CHEMBL199775 | — | Emax | = | 103.0 | % | - |
| CHEMBL200104 | — | Emax | = | 91.0 | % | - |
| CHEMBL7257 | MEBUFOTENIN | Emax | = | 89.0 | % | - |
| CHEMBL373245 | — | Emax | = | 104.0 | % | - |
| CHEMBL197653 | — | Emax | = | 100.0 | % | - |
| CHEMBL31115 | — | Emax | = | 103.0 | % | - |