Assay Detail
Binding
CHEMBL863543
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Displacement of [125I]DOI from cloned human 5HT2B receptor expressed in CHO cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-((S)-2-aminopropyl)-1H-indazol-6-ol: a potent peripherally acting 5-HT2 receptor agonist with ocular hypotensive activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 7.99 | 8.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL197653 | — | — | 1 | 8.77 |
| CHEMBL373245 | — | — | 1 | 8.42 |
| CHEMBL201132 | — | — | 1 | 8.22 |
| CHEMBL199775 | — | — | 1 | 8.12 |
| CHEMBL31115 | — | — | 1 | 8.11 |
| CHEMBL371300 | — | — | 1 | 8.09 |
| CHEMBL200104 | — | — | 1 | 8.06 |
| CHEMBL39 | SEROTONIN | 3.0 | 1 | 7.89 |
| CHEMBL275854 | — | — | 1 | 7.89 |
| CHEMBL199385 | — | — | 1 | 7.82 |
| CHEMBL134519 | — | — | 1 | 7.75 |
| CHEMBL437314 | — | — | 1 | 7.46 |
| CHEMBL7257 | MEBUFOTENIN | 2.0 | 1 | 7.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL197653 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL373245 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL201132 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL199775 | — | Ki | = | 7.5 | nM | 8.12 |
| CHEMBL31115 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL371300 | — | Ki | = | 8.1 | nM | 8.09 |
| CHEMBL200104 | — | Ki | = | 8.7 | nM | 8.06 |
| CHEMBL39 | SEROTONIN | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL275854 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL199385 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL134519 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL437314 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL7257 | MEBUFOTENIN | Ki | = | 52.0 | nM | 7.28 |