Assay Detail
Binding
CHEMBL863573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human f10a
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Preparation of 1-(4-methoxyphenyl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective and bioavailable inhibitors of coagulation factor Xa.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 8.57 | 9.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | -1.0 | 1 | 9.72 |
| CHEMBL213352 | — | — | 1 | 9.13 |
| CHEMBL384526 | — | — | 1 | 8.96 |
| CHEMBL213636 | — | — | 1 | 8.92 |
| CHEMBL212422 | — | — | 1 | 8.85 |
| CHEMBL211386 | — | — | 1 | 8.82 |
| CHEMBL379986 | — | — | 1 | 8.77 |
| CHEMBL385140 | — | — | 1 | 8.77 |
| CHEMBL437114 | — | — | 1 | 8.74 |
| CHEMBL210121 | — | — | 1 | 8.74 |
| CHEMBL211123 | — | — | 1 | 8.72 |
| CHEMBL208549 | — | — | 1 | 8.72 |
| CHEMBL212371 | — | — | 1 | 8.68 |
| CHEMBL210120 | — | — | 1 | 8.68 |
| CHEMBL212974 | — | — | 1 | 8.55 |
| CHEMBL209835 | — | — | 1 | 8.55 |
| CHEMBL384682 | — | — | 1 | 8.55 |
| CHEMBL212279 | — | — | 1 | 8.52 |
| CHEMBL378294 | — | — | 1 | 8.44 |
| CHEMBL146793 | — | — | 1 | 8.44 |
| CHEMBL379937 | — | — | 1 | 8.42 |
| CHEMBL378221 | — | — | 1 | 8.08 |
| CHEMBL211853 | — | — | 1 | 7.66 |
| CHEMBL379090 | — | — | 1 | 7.42 |
| CHEMBL211124 | — | — | 1 | 7.35 |
| CHEMBL559015 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL558198 | RAZAXABAN HYDROCHLORIDE | Ki | = | 0.19 | nM | 9.72 |
| CHEMBL213352 | — | Ki | = | 0.74 | nM | 9.13 |
| CHEMBL384526 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL213636 | — | Ki | = | 1.2 | nM | 8.92 |
| CHEMBL212422 | — | Ki | = | 1.4 | nM | 8.85 |
| CHEMBL211386 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL379986 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL385140 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL437114 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL210121 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL211123 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL208549 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL212371 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL210120 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL212974 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL209835 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL384682 | — | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL212279 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL378294 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL146793 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL379937 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL378221 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL211853 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL379090 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL211124 | — | Ki | = | 45.0 | nM | 7.35 |
| CHEMBL559015 | — | Ki | = | 0.15 | nM | - |