Assay Detail
Functional
CHEMBL863583
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Antiproliferative activity against H661 cells
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H661 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis of rigid trichostatin A analogs as HDAC inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.68 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424753 | — | — | 1 | 6.70 |
| CHEMBL374983 | — | — | 1 | 5.82 |
| CHEMBL375198 | — | — | 1 | 5.78 |
| CHEMBL386157 | — | — | 1 | 5.60 |
| CHEMBL220361 | — | — | 1 | 5.52 |
| CHEMBL218902 | — | — | 1 | 5.52 |
| CHEMBL219906 | — | — | 1 | 5.30 |
| CHEMBL373705 | — | — | 1 | 5.16 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | - |
| CHEMBL218032 | — | — | 1 | - |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424753 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL374983 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL375198 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL386157 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL220361 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL218902 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL219906 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL373705 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL99 | TRICHOSTATIN | IC50 | < | 300.0 | nM | - |
| CHEMBL218032 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL98 | VORINOSTAT | IC50 | > | 5000.0 | nM | - |