Assay Detail
Binding
CHEMBL863589
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to Grb2-SH2 domain
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Growth factor receptor-bound protein 2 (CHEMBL3663) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Application of azide-alkyne cycloaddition 'click chemistry' for the synthesis of Grb2 SH2 domain-binding macrocycles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 8.11 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL427641 | — | — | 1 | 8.96 |
| CHEMBL437910 | — | — | 1 | 8.74 |
| CHEMBL385458 | — | — | 1 | 6.64 |
| CHEMBL439177 | — | — | 1 | - |
| CHEMBL385364 | — | — | 1 | - |
| CHEMBL385459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL427641 | — | Kd | = | 1.1 | nM | 8.96 |
| CHEMBL437910 | — | Kd | = | 1.8 | nM | 8.74 |
| CHEMBL385458 | — | Kd | = | 230.0 | nM | 6.64 |
| CHEMBL439177 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL385364 | — | Kd | > | 1000.0 | nM | - |
| CHEMBL385459 | — | Kd | > | 1000.0 | nM | - |