Assay Detail
Binding
CHEMBL863603
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Inhibition of p38
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.44 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL119385 | NEFLAMAPIMOD | 2.0 | 1 | 8.00 |
| CHEMBL10 | SB-203580 | — | 1 | 6.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL119385 | NEFLAMAPIMOD | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL10 | SB-203580 | IC50 | = | 136.0 | nM | 6.87 |