Assay Detail
Binding
CHEMBL863653
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Displacement of [3H]PIPAT from human recombinant D2L receptor expressed in HEK293 cells
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-aryl-3-(4-pyridine-2-ylpiperazin-1-yl)propan-1-one oximes as potent dopamine D4 receptor agonists for the treatment of erectile dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 30 | 6.84 | 7.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL437532 | — | — | 1 | 7.71 |
| CHEMBL210101 | — | — | 1 | 7.60 |
| CHEMBL213164 | — | — | 1 | 7.33 |
| CHEMBL215450 | — | — | 1 | 7.21 |
| CHEMBL212235 | — | — | 1 | 7.20 |
| CHEMBL378324 | — | — | 1 | 7.19 |
| CHEMBL212861 | — | — | 1 | 7.17 |
| CHEMBL212903 | — | — | 1 | 7.17 |
| CHEMBL212292 | — | — | 1 | 7.12 |
| CHEMBL212784 | — | — | 1 | 7.01 |
| CHEMBL426510 | — | — | 1 | 7.00 |
| CHEMBL437687 | — | — | 1 | 6.95 |
| CHEMBL211836 | — | — | 1 | 6.90 |
| CHEMBL212782 | — | — | 1 | 6.89 |
| CHEMBL211732 | — | — | 1 | 6.88 |
| CHEMBL212444 | — | — | 1 | 6.86 |
| CHEMBL376955 | — | — | 1 | 6.85 |
| CHEMBL213004 | — | — | 1 | 6.84 |
| CHEMBL212288 | — | — | 1 | 6.79 |
| CHEMBL212969 | — | — | 1 | 6.78 |
| CHEMBL378576 | — | — | 1 | 6.77 |
| CHEMBL377050 | — | — | 1 | 6.76 |
| CHEMBL427048 | — | — | 1 | 6.66 |
| CHEMBL215705 | — | — | 1 | 6.65 |
| CHEMBL377388 | — | — | 1 | 6.59 |
| CHEMBL214314 | — | — | 1 | 6.59 |
| CHEMBL441529 | — | — | 1 | 6.43 |
| CHEMBL214247 | — | — | 1 | 6.00 |
| CHEMBL212291 | — | — | 1 | 5.74 |
| CHEMBL212891 | — | — | 1 | 5.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL437532 | — | Ki | = | 19.4 | nM | 7.71 |
| CHEMBL210101 | — | Ki | = | 25.3 | nM | 7.60 |
| CHEMBL213164 | — | Ki | = | 46.6 | nM | 7.33 |
| CHEMBL215450 | — | Ki | = | 60.9 | nM | 7.21 |
| CHEMBL212235 | — | Ki | = | 63.8 | nM | 7.20 |
| CHEMBL378324 | — | Ki | = | 64.5 | nM | 7.19 |
| CHEMBL212861 | — | Ki | = | 68.4 | nM | 7.17 |
| CHEMBL212903 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL212292 | — | Ki | = | 76.5 | nM | 7.12 |
| CHEMBL212784 | — | Ki | = | 98.7 | nM | 7.01 |
| CHEMBL426510 | — | Ki | = | 101.0 | nM | 7.00 |
| CHEMBL437687 | — | Ki | = | 112.0 | nM | 6.95 |
| CHEMBL211836 | — | Ki | = | 125.0 | nM | 6.90 |
| CHEMBL212782 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL211732 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL212444 | — | Ki | = | 137.0 | nM | 6.86 |
| CHEMBL376955 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL213004 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL212288 | — | Ki | = | 164.0 | nM | 6.79 |
| CHEMBL212969 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL378576 | — | Ki | = | 171.0 | nM | 6.77 |
| CHEMBL377050 | — | Ki | = | 172.0 | nM | 6.76 |
| CHEMBL427048 | — | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL215705 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL377388 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL214314 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL441529 | — | Ki | = | 368.0 | nM | 6.43 |
| CHEMBL214247 | — | Ki | = | 995.0 | nM | 6.00 |
| CHEMBL212291 | — | Ki | = | 1820.0 | nM | 5.74 |
| CHEMBL212891 | — | Ki | = | 2530.0 | nM | 5.60 |